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Article

Clinical Targeted Next-Generation Sequencing Shows Increased Mutational Load in Endometrioid-type Endometrial Adenocarcinoma With Deficient DNA Mismatch Repair.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Nov 2018

Lee Paul J, McNulty Samantha, Duncavage Eric J, Heusel Jonathan W, Hagemann Ian S

Abstract excerpt

A subset of endometrial adenocarcinomas (EACs) exhibit microsatellite instability and have deficient DNA mismatch repair (dMMR). The overall aim of the study was to compare the spectrum of mutations in endometrioid-type EAC with and without dMMR by using a clinically validated next-generation sequencing assay. We retrospectively identified 19 EACs with known mismatch repair status that had undergone targeted...

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Topics

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Share to Carcinoma, Endometrioid
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to High-Throughput Nucleotide Sequencing

Share to Microsatellite Instability

Share to Mismatch Repair Endonuclease PMS2

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Source

Identifiers

PMID: 29084048
DOI: 10.1097/PGP.0000000000000459

Genes

ATM
FLT3
MLH1
MSH2
MSH6
PMS2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Clinical Targeted Next-Generation Sequencing Shows Increased Mutational Load in Endometrioid-type Endometrial Adenocarcinoma With Deficient DNA Mismatch Repair.PMID 29084048Read ↗

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