Article
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production.
PLoS genetics - 1 Jan 2013
Molineros Julio E, Maiti Amit K, Sun Celi, Looger Loren L, Han Shizhong, Kim-Howard Xana, Glenn Stuart, Adler Adam, Kelly Jennifer A, Niewold Timothy B, Gilkeson Gary S, Brown Elizabeth E, Alarcón Graciela S, Edberg Jeffrey C, Petri Michelle, Ramsey-Goldman Rosalind, Reveille John D, Vilá Luis M, Freedman Barry I, Tsao Betty P, Criswell Lindsey A, Jacob Chaim O, Moore Jason H, Vyse Timothy J, Langefeld Carl L, Guthridge Joel M, Gaffney Patrick M, Moser Kathy L, Scofield R Hal, Alarcón-Riquelme Marta E, Williams Scott M, Merrill Joan T, James Judith A, Kaufman Kenneth M, Kimberly Robert P, Harley John B, Nath Swapan K
Abstract excerpt
Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease with a strong genetic component. African-Americans (AA) are at increased risk of SLE, but the genetic basis of this risk is largely unknown. To identify causal variants in SLE loci in AA, we performed admixture mapping followed by fine mapping in AA and European-Americans (EA). Through genome-wide admixture mapping in AA, we identified a...
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