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Article

Giantin is required for coordinated production of aggrecan, link protein and type XI collagen during chondrogenesis.

Biochemical and biophysical research communications - 15 May 2018

Katayama Kentaro, Kuriki Mao, Kamiya Tomoyo, Tochigi Yuki, Suzuki Hiroetsu

Abstract excerpt

Extracellular matrix (ECM) constitutes a proper micro-environment for cell proliferation, migration and differentiation, as well as playing pivotal roles in developmental processes including endochondral ossification. Cartilage ECM is mainly composed of fibrous proteins, including collagen, proteoglycan, and hyaluronan. Because almost all ECM components are transported by intracellular vesicular transport...

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PMID: 29577904
DOI: 10.1016/j.bbrc.2018.03.163

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