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Article

Collagen XI mutation lowers susceptibility to load-induced cartilage damage in mice.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Feb 2018

Holyoak Derek T, Otero Miguel, Armar Naa Shidaa, Ziemian Sophia N, Otto Ariana, Cullinane Devinne, Wright Timothy M, Goldring Steven R, Goldring Mary B, van der Meulen Marjolein C H

Abstract excerpt

Interactions among risk factors for osteoarthritis (OA) are not well understood. We investigated the combined impact of two prevalent risk factors: mechanical loading and genetically abnormal cartilage tissue properties. We used cyclic tibial compression to simulate mechanical loading in the cho/+ (Col11a1 haploinsufficient) mouse, which has abnormal collagen fibrils in cartilage due to a point mutation in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28898438
DOI: 10.1002/jor.23731
PMCID: PMC8813548

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