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Article

The p.P888L SAP97 polymorphism increases the transient outward current (Ito,f) and abbreviates the action potential duration and the QT interval.

Scientific reports - 1 Jul 2020

Tinaquero David, Crespo-García Teresa, Utrilla Raquel G, Nieto-Marín Paloma, González-Guerra Andrés, Rubio-Alarcón Marcos, Cámara-Checa Anabel, Dago María, Matamoros Marcos, Pérez-Hernández Marta, Tamargo María, Cebrián Jorge, Jalife José, Tamargo Juan, Bernal Juan Antonio, Caballero Ricardo, Delpón Eva

Abstract excerpt

Synapse-Associated Protein 97 (SAP97) is an anchoring protein that in cardiomyocytes targets to the membrane and regulates Na+ and K+ channels. Here we compared the electrophysiological effects of native (WT) and p.P888L SAP97, a common polymorphism. Currents were recorded in cardiomyocytes from mice trans-expressing human WT or p.P888L SAP97 and in Chinese hamster ovary (CHO)-transfected cells. The duration of...

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Identifiers

PMID: 32612162
DOI: 10.1038/s41598-020-67109-z
PMCID: PMC7329876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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