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Article

Cytoplasmic inter-subunit interface modulates TRPC5 activity: Molecular mechanism behind intellectual disability-related R175C mutation.

Neurobiology of disease - 15 Oct 2025

Mitro Michal, Ptáková Alexandra, Vlachová Viktorie, Zímová Lucie

Abstract excerpt

The TRPC5 (Transient Receptor Potential Canonical 5) receptor, which is highly expressed in the brain, kidney, and sensory neurons, is emerging as a pharmacological target due to its involvement in renal physiology, pain, metabolic homeostasis, and various neurodevelopmental disorders. The recently identified R175C mutation associated with intellectual disability and autism spectrum disorders has supported the...

Topics

TRPC Cation Channels
Intellectual Disability
Humans
Mutation
HEK293 Cells
Cytoplasm
Animals

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40907672
DOI: 10.1016/j.nbd.2025.107082

Genes

TRPC5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-40907672-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Cytoplasmic inter-subunit interface modulates TRPC5 activity: Molecular mechanism behind intellectual disability-related R175C mutation.PMID 40907672Read ↗

TRPC5.Semantic proximity Read ↗

The S4---S5 linker - gearbox of TRP channel gating.Semantic proximity Read ↗

Structure of the receptor-activated human TRPC6 ion channelSemantic proximity Read ↗

Structure of full-length human TRPM4Semantic proximity Read ↗

Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state.Semantic proximity Read ↗

A competing hydrophobic tug on L596 to the membrane core unlatches S4-S5 linker elbow from TRP helix and allows TRPV4 channel to open.Semantic proximity Read ↗

Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating.Semantic proximity Read ↗

TRPM7.Semantic proximity Read ↗

Cryo-EM structures of human TRPC5 reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding siteSemantic proximity Read ↗

Unraveling pH Regulation of TMEM175, an Endolysosomal Cation Channel With a Role in Parkinson's Disease.Semantic proximity Read ↗

L596-W733 bond between the start of the S4-S5 linker and the TRP box stabilizes the closed state of TRPV4 channel.Semantic proximity Read ↗

Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complexSemantic proximity Read ↗

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