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Article

Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases.

Neuropharmacology - 1 Jan 1996

Kim E, Sheng M

Abstract excerpt

The molecular mechanisms underlying the clustering and localization of K+ channels in specific microdomains on the neuronal surface are largely unknown. The Shaker subclass of voltage-gated K+ channel alpha-subunits interact through their cytoplasmic C-terminus with a family of membrane-associated putative guanylate kinases, including PSD-95 and SAP97. We show here that heterologous coexpression of either sap97...

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Source

Identifiers

PMID: 8938729
DOI: 10.1016/0028-3908(96)00093-7

Genes

PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases.PMID 8938729Read ↗

Requirement of N-terminal cysteines of PSD-95 for PSD-95 multimerization and ternary complex formation, but not for binding to potassium channel Kv1.4.Semantic proximity Read ↗

Different Isoforms of Synapse-associated Protein, SAP97, Are Expressed in the Heart and Have Distinct Effects on the Voltage-gated K+ Channel Kv1.5Semantic proximity Read ↗

An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1.Semantic proximity Read ↗

Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs.Semantic proximity Read ↗

Kv beta 1 subunit binding specific for shaker-related potassium channel alpha subunits.Semantic proximity Read ↗

Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1.Semantic proximity Read ↗

Epileptic encephalopathy-related Kv2.1 mutants impair channel clustering and membrane distribution but not neuronal excitabilitySemantic proximity Read ↗

Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97.Semantic proximity Read ↗

Heteromultimeric interactions among K+ channel subunits from Shaker and eag families in Xenopus oocytes.Semantic proximity Read ↗

Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5.Semantic proximity Read ↗

A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.Semantic proximity Read ↗

The p.P888L SAP97 polymorphism increases the transient outward current (Ito,f) and abbreviates the action potential duration and the QT interval.Semantic proximity Read ↗

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