Article
Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing.
The American journal of physiology - 1 Dec 1998
Kong W, Po S, Yamagishi T, Ashen M D, Stetten G, Tomaselli G F
Abstract excerpt
The transient outward K+ current (Ito) in the heart is responsible for the initial phase of repolarization and for setting the plateau voltage of the ventricular action potential. Recently, Kv4.3 has emerged as the leading candidate alpha-subunit gene that underlies Ito in larger mammals such as...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Cells, Cultured
- Chromosome Mapping
- Cloning, Molecular
- DNA, Complementary
- Genes
- Genetic Variation
- Genome, Human
- Humans
- Mice
- Molecular Sequence Data
- Potassium Channels
- Potassium Channels, Voltage-Gated
- RNA, Messenger
- Shal Potassium Channels