Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SUMOylation and an ATS1 variant converge to disrupt PIP2-dependent gating of Kir2.1.

The Journal of general physiology - 3 Nov 2025

Chandrashekar Aishwarya, Xu Yu, Ma Xinyi, Yauch Anne K, Scholl Elizabeth, Yang Yuchen, Gada Kirin D, Kawano Takeharu, Cui Meng, Plant Leigh D

Abstract excerpt

Precise control of Kir2.1 channel gating is essential for maintaining membrane potential and enabling repolarization in excitable cells. Disruption of Kir2.1 function can cause Andersen-Tawil syndrome type 1 (ATS1), a multisystem channelopathy that predisposes patients to ventricular dysrhythmias and increases the risk of sudden cardiac death. Kir2.1 activity depends on interactions with the membrane phospholipid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Andersen Syndrome
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to Mutation

Share to Phosphatidylinositol 4,5-Diphosphate

Share to Potassium Channels, Inwardly Rectifying

Share to Sumoylation

Source

Identifiers

PMID: 41085580
DOI: 10.1085/jgp.202513837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SUMOylation and an ATS1 variant converge to disrupt PIP2-dependent gating of Kir2.1.PMID 41085580Read ↗

Hypoxia Exacerbates Kir2.1 Channel Dysfunction in an Andersen-Tawil Syndrome Variant Through a SUMO-Dependent MechanismSemantic proximity Read ↗

Sumoylation silences the plasma membrane leak K+ channel K2P1.Semantic proximity Read ↗

Risk Stratification of Arrhythmogenic Consequences of Andersen-Tawil Syndrome Affecting Kir2.1-PIP2 InteractionsSemantic proximity Read ↗

Biochemical, biophysical, and structural investigations of two mutants (C154Y and R312H) of the human Kir2.1 channel involved in the Andersen-Tawil syndrome.Semantic proximity Read ↗

Biochemical, biophysical, and structural investigations of two mutants (C154Y and R312H) of the human Kir2.1 channel involved in the Andersen-Tawil syndromeSemantic proximity Read ↗

T75M-KCNJ2 mutation causing Andersen-Tawil syndrome enhances inward rectification by changing Mg2+ sensitivity.Semantic proximity Read ↗

Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents.Semantic proximity Read ↗

PIP <sub>2</sub> stabilizes Na <sub>V</sub> 1.5 gating and links receptor signaling to cardiac late sodium currentSemantic proximity Read ↗

OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant.Semantic proximity Read ↗

Extracellular Kir2.1C122Y Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome.Semantic proximity Read ↗

Variable loss of Kir4.1 channel function in SeSAME syndrome mutations.Semantic proximity Read ↗

Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.