Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval.

Heart rhythm - 1 Dec 2007

Lundby Alicia, Ravn Lasse Steen, Svendsen Jesper Hastrup, Olesen Søren-Peter, Schmitt Nicole

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) and long QT syndrome (LQTS) are cardiac arrhythmia disorders that have been related to dysfunction of the voltage-gated potassium channel subunit Kv7.1 encoded by the KCNQ1 gene. OBJECTIVE: The purpose of this study was functional assessment of a mutation in Kv7.1 identified in a proband with permanent AF and prolonged QT interval. We investigated whether this KCNQ1 missense...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrial Fibrillation
Share to CHO Cells
Share to Cricetinae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetulus

Share to Gene Expression Regulation

Share to KCNQ1 Potassium Channel

Share to Oocytes

Share to Xenopus laevis

Source

Identifiers

PMID: 17997361
DOI: 10.1016/j.hrthm.2007.07.022

Genes

KCNQ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval.PMID 17997361Read ↗

Kv7.1 (KCNQ1) properties and channelopathies.Semantic proximity Read ↗

Functional phenotype variations of two novel KV 7.1 mutations identified in patients with Long QT syndrome.Semantic proximity Read ↗

A new KCNQ1 mutation at the S5 segment that impairs its association with KCNE1 is responsible for short QT syndrome.Semantic proximity Read ↗

R231C mutation in KCNQ1 causes long QT syndrome type 1 and familial atrial fibrillation.Semantic proximity Read ↗

Sodium overload due to a persistent current that attenuates the arrhythmogenic potential of a novel LQT3 mutationSemantic proximity Read ↗

A KCNQ1 mutation causes a high penetrance for familial atrial fibrillation.Semantic proximity Read ↗

De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in uteroSemantic proximity Read ↗

KCNQ1 gain-of-function mutation in familial atrial fibrillation.Semantic proximity Read ↗

A novel gain-of-function KCNJ2 mutation associated with short-QT syndrome impairs inward rectification of Kir2.1 currents.Semantic proximity Read ↗

Combination of cardiac conduction disease and long QT syndrome caused by mutation T1620K in the cardiac sodium channel.Semantic proximity Read ↗

Functional Characterization of a Spectrum of Novel Romano-Ward Syndrome KCNQ1 Variants.Semantic proximity Read ↗

IKs Gain- and Loss-of-Function in Early-Onset Lone Atrial Fibrillation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.