Article
The expression of the rare caveolin-3 variant T78M alters cardiac ion channels function and membrane excitability.
Cardiovascular research - 1 Aug 2017
Campostrini Giulia, Bonzanni Mattia, Lissoni Alessio, Bazzini Claudia, Milanesi Raffaella, Vezzoli Elena, Francolini Maura, Baruscotti Mirko, Bucchi Annalisa, Rivolta Ilaria, Fantini Matteo, Severi Stefano, Cappato Riccardo, Crotti Lia, J Schwartz Peter, DiFrancesco Dario, Barbuti Andrea
Abstract excerpt
AIMS: Caveolinopathies are a family of genetic disorders arising from alterations of the caveolin-3 (cav-3) gene. The T78M cav-3 variant has been associated with both skeletal and cardiac muscle pathologies but its functional contribution, especially to cardiac diseases, is still controversial. Here, we evaluated the effect of the T78M cav-3 variant on cardiac ion channel function and membrane excitability....
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