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Article

Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe.

Cell death & disease - 1 Jul 2020

Gastl Bastian, Klotz-Noack Kathleen, Klinger Bertram, Ispasanie Sylvia, Salib Krenoula Hani Fouad, Zuber Johannes, Mamlouk Soulafa, Bublitz Natalie, Blüthgen Nils, Horst David, Morkel Markus, Schäfer Reinhold, Sers Christine

Abstract excerpt

To unravel vulnerabilities of KRAS-mutant CRC cells, a shRNA-based screen specifically inhibiting MAPK pathway components and targets was performed in CaCo2 cells harboring conditional oncogenic KRASG12V. The custom-designed shRNA library comprised 121 selected genes, which were previously identified to be strongly regulated in response to MEK inhibition. The screen showed that CaCo2 cells expressing KRASG12V...

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Identifiers

PMID: 32612138
DOI: 10.1038/s41419-020-2704-9
PMCID: PMC7330027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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