CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells.

doi:10.1136/gutjnl-2016-312623

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CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells.

Gut - 1 May 2018

Manic Gwenola, Signore Michele, Sistigu Antonella, Russo Giorgio, Corradi Francesca, Siteni Silvia, Musella Martina, Vitale Sara, De Angelis Maria Laura, Pallocca Matteo, Amoreo Carla Azzurra, Sperati Francesca, Di Franco Simone, Barresi Sabina, Policicchio Eleonora, De Luca Gabriele, De Nicola Francesca, Mottolese Marcella, Zeuner Ann, Fanciulli Maurizio, Stassi Giorgio, Maugeri-Saccà Marcello, Baiocchi Marta, Tartaglia Marco, Vitale Ilio, De Maria Ruggero

Abstract excerpt

OBJECTIVE: Cancer stem cells (CSCs) are responsible for tumour formation and spreading, and their targeting is required for tumour eradication. There are limited therapeutic options for advanced colorectal cancer (CRC), particularly for tumours carrying RAS-activating mutations. The aim of this study was to identify novel CSC-targeting strategies. DESIGN: To discover potential therapeutics to be clinically...

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PMID: 28389531
DOI: 10.1136/gutjnl-2016-312623
PMCID: PMC5890648

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