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Article

CDC7 stabilized by KRAS signaling reactivation impairs chemosensitivity in KRAS-mutant colorectal cancer.

Pharmacological research - 1 Dec 2025

Wu Ruilin, Liu Yue, Fu Junwei, Zhou Tianhua, Hu Ronggui, Yang Bo, He Qiaojun, Yuan Tao, Zhu Hong

Abstract excerpt

KRAS, the most frequently mutated oncogene in colorectal cancer (CRC), presents a formidable therapeutic challenge. While 5-fluorouracil (5-FU) and oxaliplatin remain the cornerstone of chemotherapy for KRAS-mutant CRC, their efficacy is frequently undermined by intrinsic and acquired resistance. Unravelling the shared mechanisms underlying sensitivity to both 5-FU and oxaliplatin could unveil novel strategies to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Neoplasm

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Source

Identifiers

PMID: 41207349
DOI: 10.1016/j.phrs.2025.108027

Genes

CDC7
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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