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Article

Targeting the DNA replication stress phenotype of KRAS mutant cancer cells.

Scientific reports - 11 Feb 2021

Al Zubaidi Tara, Gehrisch O H Fiete, Genois Marie-Michelle, Liu Qi, Lu Shan, Kung Jong, Xie Yunhe, Schuemann Jan, Lu Hsiao-Ming, Hata Aaron N, Zou Lee, Borgmann Kerstin, Willers Henning

Abstract excerpt

Mutant KRAS is a common tumor driver and frequently confers resistance to anti-cancer treatments such as radiation. DNA replication stress in these tumors may constitute a therapeutic liability but is poorly understood. Here, using single-molecule DNA fiber analysis, we first characterized baseline replication stress in a panel of unperturbed isogenic and non-isogenic cancer cell lines. Correlating with the...

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Identifiers

PMID: 33574444
DOI: 10.1038/s41598-021-83142-y
PMCID: PMC7878884

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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