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Article

Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2.

Antiviral therapy - 1 Jan 2011

Sauerbrei Andreas, Bohn Kathrin, Heim Albert, Hofmann Jörg, Weissbrich Benedikt, Schnitzler Paul, Hoffmann Dieter, Zell Roland, Jahn Gerhard, Wutzler Peter, Hamprecht Klaus

Abstract excerpt

BACKGROUND: Studies to verify correlations between phenotypes and genotypes of herpes simplex virus (HSV) are an important tool to establish a database of resistance-associated mutations. METHODS: In this study, 32 acyclovir (ACV)-resistant clinical HSV-1 and 4 ACV-resistant clinical HSV-2 isolates were examined in parallel by both phenotypic and genotypic resistance testing. Additionally, five non-viable HSV-1...

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Identifiers

PMID: 22155911
DOI: 10.3851/IMP1870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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