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Expression of herpes simplex virus type 1 recombinant thymidine kinase and its application to a rapid antiviral sensitivity assay.

Antiviral research - 1 Aug 2011

Shiota Tomoyuki, Lixin Wang, Takayama-Ito Mutsuyo, Iizuka Itoe, Ogata Momoko, Tsuji Masanori, Nishimura Hidekazu, Taniguchi Shuichi, Morikawa Shigeru, Kurane Ichiro, Mizuguchi Masashi, Saijo Masayuki

Abstract excerpt

Antiviral-resistant herpesvirus infection has become a great concern for immunocompromised patients. Herpes simplex virus type 1 (HSV-1) infections are treated with viral thymidine kinase (vTK)-associated drugs such as acyclovir (ACV), and most ACV-resistance (ACV(r)) is due to mutations in the vTK. The standard drug sensitivity test is usually carried out by the plaque reduction assay-based method, which...

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Identifiers

PMID: 21669227
DOI: 10.1016/j.antiviral.2011.05.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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