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Variant Analysis of the Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus in Korea: Frequency of Acyclovir Resistance Mutations.

Viruses - 9 Aug 2023

Hyun Jungwon, Lee Su Kyung, Kim Ji Hyun, Cho Eun-Jung, Kim Han-Sung, Kim Jae-Seok, Song Wonkeun, Kim Hyun Soo

Abstract excerpt

The thymidine kinase (TK) and DNA polymerase (pol) genes of the herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) are two important genes involved in antiviral resistance. We investigated the genetic polymorphisms of the HSV-TK and pol genes in clinical isolates from Korean HSV-infected patients using next-generation sequencing (NGS) for the first time in Korea. A total of 81 HSV-1 and 47 HSV-2 isolates...

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Source

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Identifiers

PMID: 37632051
DOI: 10.3390/v15081709
PMCID: PMC10458183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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