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Article

Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope.

Nature communications - 23 May 2017

Rouvinski Alexander, Dejnirattisai Wanwisa, Guardado-Calvo Pablo, Vaney Marie-Christine, Sharma Arvind, Duquerroy Stéphane, Supasa Piyada, Wongwiwat Wiyada, Haouz Ahmed, Barba-Spaeth Giovanna, Mongkolsapaya Juthathip, Rey Félix A, Screaton Gavin R

Abstract excerpt

A problem in the search for an efficient vaccine against dengue virus is the immunodominance of the fusion loop epitope (FLE), a segment of the envelope protein E that is buried at the interface of the E dimers coating mature viral particles. Anti-FLE antibodies are broadly cross-reactive but poorly neutralizing, displaying a strong infection enhancing potential. FLE exposure takes place via dynamic 'breathing'...

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Identifiers

PMID: 28534525
DOI: 10.1038/ncomms15411
PMCID: PMC5457521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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