Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Water-mediated biomolecular dynamics and allostery.

The Journal of chemical physics - 28 Jun 2020

Leitner David M, Hyeon Changbong, Reid Korey M

Abstract excerpt

Dynamic coupling with water contributes to regulating the functional dynamics of a biomolecule. We discuss protein-water dynamics, with emphasis on water that is partially confined, and the role of protein-confined water dynamics in allosteric regulation. These properties are illustrated with two systems, a homodimeric hemoglobin from Scapharca inaequivalvis (HbI) and an A2A adenosine receptor (A2AAR). For HbI,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Regulation
Share to Allosteric Site
Share to Energy Transfer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemoglobins

Share to Hydrogen Bonding

Share to Protein Domains

Share to Receptor, Adenosine A2A

Source

Identifiers

PMID: 32610961
DOI: 10.1063/5.0011392

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Water-mediated biomolecular dynamics and allostery.PMID 32610961Read ↗

Water-mediated conformational preselection mechanism in substrate binding cooperativity to protein kinase A.Semantic proximity Read ↗

Using buried water molecules to explore the energy landscape of proteins.Semantic proximity Read ↗

Entropy-Driven Protein Allosteric Effect in Cells Highlights the Role of Solvation Water Molecules.Semantic proximity Read ↗

Functional plasticity and evolutionary adaptation of allosteric regulation.Semantic proximity Read ↗

Water's Variable Role in Protein Stability Uncovered by Liquid-Observed Vapor Exchange NMR.Semantic proximity Read ↗

The mutation K30D disrupts the only salt bridge at the subunit interface of the homodimeric hemoglobin from Scapharca inaequivalvis and changes the mechanism of cooperativity.Semantic proximity Read ↗

50 years of allosteric interactions: the twists and turns of the models.Semantic proximity Read ↗

Trapped water molecules are essential to structural dynamics and function of a ribozyme.Semantic proximity Read ↗

Probing water micro-solvation in proteins by water catalysed proton-transfer tautomerism.Semantic proximity Read ↗

Protein Allostery Study in Cells Using NMR Spectroscopy.Semantic proximity Read ↗

The origin of allosteric functional modulation: multiple pre-existing pathways.Semantic proximity Read ↗

On the Relationship Between Protein Stability, Thermostability, and Allosteric Signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.