Article
Probing water micro-solvation in proteins by water catalysed proton-transfer tautomerism.
Nature communications - 1 Jan 2013
Shen Jiun-Yi, Chao Wei-Chih, Liu Chun, Pan Hsiao-An, Yang Hsiao-Ching, Chen Chi-Lin, Lan Yi-Kang, Lin Li-Ju, Wang Jinn-Shyan, Lu Jyh-Feng, Chun-Wei Chou Steven, Tang Kuo-Chun, Chou Pi-Tai
Abstract excerpt
Scientists have made tremendous efforts to gain understanding of the water molecules in proteins via indirect measurements such as molecular dynamic simulation and/or probing the polarity of the local environment. Here we present a tryptophan analogue that exhibits remarkable water catalysed proton-transfer properties. The resulting multiple emissions provide unique fingerprints that can be exploited for direct...
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