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Article

On the Relationship Between Protein Stability, Thermostability, and Allosteric Signaling.

Journal of molecular biology - 15 Feb 2026

Raechell, Tee Wei-Ven, Dong Bingxue, Guarnera Enrico, Berezovsky Igor N

Abstract excerpt

The thermodynamic stability of proteins and regulation of their functional activity can be described within the energy landscape framework, where the former is provided by a unique native conformational ensemble separated by an energy gap from misfolded structures, and the latter is based on conformational transitions between structural states in the native ensemble. This work investigates the relationship...

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Identifiers

PMID: 41223935
DOI: 10.1016/j.jmb.2025.169537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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