Entropy-Driven Protein Allosteric Effect in Cells Highlights the Role of Solvation Water Molecules.

Abstract excerpt

Allosteric effects are critical for protein function. The mechanisms by which allosteric effects propagate in cellular environments remain intriguing yet unresolved questions. In this study, we investigated the allosteric effects involved in a protein-protein binding process within Escherichia coli cells. Mutations far away from the binding interface were introduced, which alter the affinity through allosteric...

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