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Article

Water's Variable Role in Protein Stability Uncovered by Liquid-Observed Vapor Exchange NMR.

Biochemistry - 19 Oct 2021

Crilly Candice J, Eicher Jonathan E, Warmuth Owen, Atkin Joanna M, Pielak Gary J

Abstract excerpt

Water is essential to protein structure and stability, yet our understanding of how water shapes proteins is far from thorough. Our incomplete knowledge of protein-water interactions is due in part to a long-standing technological inability to assess experimentally how water removal impacts local protein structure. It is now possible to obtain residue-level information on dehydrated protein structures via...

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PMID: 34596383
DOI: 10.1021/acs.biochem.1c00552
PMCID: PMC8609290

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