Article
Multi-Ethnic Genome-Wide Association Study of Decomposed Cardioelectric Phenotypes Illustrates Strategies to Identify and Characterize Evidence of Shared Genetic Effects for Complex Traits.
Circulation. Genomic and precision medicine - 1 Aug 2020
Baldassari Antoine R, Sitlani Colleen M, Highland Heather M, Arking Dan E, Buyske Steve, Darbar Dawood, Gondalia Rahul, Graff Misa, Guo Xiuqing, Heckbert Susan R, Hindorff Lucia A, Hodonsky Chani J, Ida Chen Yii-Der, Kaplan Robert C, Peters Ulrike, Post Wendy, Reiner Alex P, Rotter Jerome I, Shohet Ralph V, Seyerle Amanda A, Sotoodehnia Nona, Tao Ran, Taylor Kent D, Wojcik Genevieve L, Yao Jie, Kenny Eimear E, Lin Henry J, Soliman Elsayed Z, Whitsel Eric A, North Kari E, Kooperberg Charles, Avery Christy L
Abstract excerpt
BACKGROUND: We examined how expanding electrocardiographic trait genome-wide association studies to include ancestrally diverse populations, prioritize more precise phenotypic measures, and evaluate evidence for shared genetic effects enabled the detection and characterization of loci. METHODS: We decomposed 10 seconds, 12-lead electrocardiograms from 34 668 multi-ethnic participants (15% Black; 30%...
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