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Article

Genome-Wide Associations of Global Electrical Heterogeneity ECG Phenotype: The ARIC (Atherosclerosis Risk in Communities) Study and CHS (Cardiovascular Health Study).

Journal of the American Heart Association - 5 Apr 2018

Tereshchenko Larisa G, Sotoodehnia Nona, Sitlani Colleen M, Ashar Foram N, Kabir Muammar, Biggs Mary L, Morley Michael P, Waks Jonathan W, Soliman Elsayed Z, Buxton Alfred E, Biering-Sørensen Tor, Solomon Scott D, Post Wendy S, Cappola Thomas P, Siscovick David S, Arking Dan E

Abstract excerpt

BACKGROUND: ECG global electrical heterogeneity (GEH) is associated with sudden cardiac death. We hypothesized that a genome-wide association study would identify genetic loci related to GEH. METHODS AND RESULTS: We tested genotyped and imputed variants in black (N=3057) and white (N=10 769) participants in the ARIC (Atherosclerosis Risk in Communities) study and CHS (Cardiovascular Health Study). GEH (QRS-T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29622589
DOI: 10.1161/JAHA.117.008160
PMCID: PMC6015433

Genes

HMCN2
IGF1R
ACTB
NDRG4
TBX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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