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Article

Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes.

Circulation. Cardiovascular genetics - 1 Apr 2017

Mosley Jonathan D, Shoemaker M Benjamin, Wells Quinn S, Darbar Dawood, Shaffer Christian M, Edwards Todd L, Bastarache Lisa, McCarty Catherine A, Thompson Will, Chute Christopher G, Jarvik Gail P, Crosslin David R, Larson Eric B, Kullo Iftikhar J, Pacheco Jennifer A, Peissig Peggy L, Brilliant Murray H, Linneman James G, Witte John S, Denny Josh C, Roden Dan M

Abstract excerpt

BACKGROUND: One potential use for the PR interval is as a biomarker of disease risk. We hypothesized that quantifying the shared genetic architectures of the PR interval and a set of clinical phenotypes would identify genetic mechanisms contributing to PR variability and identify diseases associated with a genetic predictor of PR variability. METHODS AND RESULTS: We used ECG measurements from the ARIC study...

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Identifiers

PMID: 28416512
DOI: 10.1161/CIRCGENETICS.116.001482
PMCID: PMC5434456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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