Article
Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.
Circulation. Cardiovascular genetics - 1 Dec 2012
Butler Anne M, Yin Xiaoyan, Evans Daniel S, Nalls Michael A, Smith Erin N, Tanaka Toshiko, Li Guo, Buxbaum Sarah G, Whitsel Eric A, Alonso Alvaro, Arking Dan E, Benjamin Emelia J, Berenson Gerald S, Bis Josh C, Chen Wei, Deo Rajat, Ellinor Patrick T, Heckbert Susan R, Heiss Gerardo, Hsueh Wen-Chi, Keating Brendan J, Kerr Kathleen F, Li Yun, Limacher Marian C, Liu Yongmei, Lubitz Steven A, Marciante Kristin D, Mehra Reena, Meng Yan A, Newman Anne B, Newton-Cheh Christopher, North Kari E, Palmer Cameron D, Psaty Bruce M, Quibrera P Miguel, Redline Susan, Reiner Alex P, Rotter Jerome I, Schnabel Renate B, Schork Nicholas J, Singleton Andrew B, Smith J Gustav, Soliman Elsayed Z, Srinivasan Sathanur R, Zhang Zhu-ming, Zonderman Alan B, Ferrucci Luigi, Murray Sarah S, Evans Michele K, Sotoodehnia Nona, Magnani Jared W, Avery Christy L
Abstract excerpt
BACKGROUND: The PR interval, as measured by the resting, standard 12-lead ECG, reflects the duration of atrial/atrioventricular nodal depolarization. Substantial evidence exists for a genetic contribution to PR, including genome-wide association studies that have identified common genetic variants at 9 loci influencing PR in populations of European and Asian descent. However, few studies have examined loci...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.