Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Validation of Polygenic Scores for QT Interval in Clinical Populations.

Circulation. Cardiovascular genetics - 1 Oct 2017

Rosenberg Michael A, Lubitz Steven A, Lin Honghuang, Kosova Gulum, Castro Victor M, Huang Paul, Ellinor Patrick T, Perlis Roy H, Newton-Cheh Christopher

Abstract excerpt

BACKGROUND: Polygenic risk scores (PGS) enable rapid estimation of genome-wide susceptibility for traits, which may be useful in clinical settings, such as prediction of QT interval. In this study, we sought to validate PGS for QT interval in 2 real-world cohorts of European ancestry (EA) and African ancestry (AA). METHODS AND RESULTS: Two thousand nine hundred and fifteen participants of EA and 366 of AA in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black People
Share to CAMP gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Long QT Syndrome

Share to Metabolic Diseases

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 28986454
DOI: 10.1161/CIRCGENETICS.117.001724
PMCID: PMC5679734

Genes

CAMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Validation of Polygenic Scores for QT Interval in Clinical Populations.PMID 28986454Read ↗

Genome-Wide Association Study for Resting Electrocardiogram in the Qatari Population Identifies 6 Novel Genes and Validates Novel Polygenic Risk Scores.Semantic proximity Read ↗

Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings.Semantic proximity Read ↗

Use of Polygenic Risk Scores for Coronary Heart Disease in Ancestrally Diverse Populations.Semantic proximity Read ↗

Multi-trait polygenic risk scores improve genomic prediction of atrial fibrillation across diverse ancestriesSemantic proximity Read ↗

Monogenic and Polygenic Contributions to QTc Prolongation in the PopulationSemantic proximity Read ↗

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarizationSemantic proximity Read ↗

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathwaysSemantic proximity Read ↗

Multi-Ethnic Genome-Wide Association Study of Decomposed Cardioelectric Phenotypes Illustrates Strategies to Identify and Characterize Evidence of Shared Genetic Effects for Complex Traits.Semantic proximity Read ↗

Corrected QT Interval-Polygenic Risk Score and Its Contribution to Type 1, Type 2, and Type 3 Long-QT Syndrome in Probands and Genotype-Positive Family Members.Semantic proximity Read ↗

Genetic QT Score and Sleep Apnea as Predictors of Sudden Cardiac Death in the UK BiobankSemantic proximity Read ↗

Genetic QT score as a predictor of sudden cardiac death in participants with sleep-disordered breathing in the UK Biobank.Semantic proximity Read ↗

Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.