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Article

Novel spirothiazamenthane inhibitors of the influenza A M2 proton channel.

European journal of medicinal chemistry - 14 Sept 2016

Arns Steve, Balgi Aruna D, Shimizu Yoko, Pfeifer Tom A, Kumar Nag, Shidmoossavee Fahimeh S, Sun Sharon, Tai Sheldon S-H, Agafitei Olga, Jaquith James B, Bourque Elyse, Niikura Masahiro, Roberge Michel

Abstract excerpt

The development of treatments for influenza that inhibit the M2 proton channel without being susceptible to the widespread resistance mechanisms associated with the adamantanes is an ongoing challenge. Using a yeast high-throughput yeast growth restoration assay designed to identify M2 channel inhibitors, a single screening hit was uncovered. This compound (3), whose structure was incorrectly identified in the...

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Identifiers

PMID: 27187859
DOI: 10.1016/j.ejmech.2016.05.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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