Association between PNPLA3 rs738409 G variant and MRI cerebrovascular disease biomarkers.

doi:10.1016/j.jns.2020.116981

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Article

Association between PNPLA3 rs738409 G variant and MRI cerebrovascular disease biomarkers.

Journal of the neurological sciences - 15 Sept 2020

Parikh Neal S, Dueker Nicole, Varela Dalila, Del Brutto Victor J, Rundek Tatjana, Wright Clinton B, Sacco Ralph L, Elkind Mitchell S V, Gutierrez Jose

Abstract excerpt

INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) has been associated with greater cerebral white matter hyperintensity (WMH) volume and microbleeds. The adiponutrin (PNPLA3) rs738409 G variant, a robust NAFLD susceptibility variant, has been variably associated with carotid atherosclerosis. We hypothesized that this variant is associated with WMH volume, microbleeds, covert brain infarction (CBI), and small...

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Identifiers

PMID: 32592869
DOI: 10.1016/j.jns.2020.116981
PMCID: PMC9004230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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