Article
Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.
Stroke - 1 Aug 2018
Jian Xueqiu, Satizabal Claudia L, Smith Albert V, Wittfeld Katharina, Bis Joshua C, Smith Jennifer A, Hsu Fang-Chi, Nho Kwangsik, Hofer Edith, Hagenaars Saskia P, Nyquist Paul A, Mishra Aniket, Adams Hieab H H, Li Shuo, Teumer Alexander, Zhao Wei, Freedman Barry I, Saba Yasaman, Yanek Lisa R, Chauhan Ganesh, van Buchem Mark A, Cushman Mary, Royle Natalie A, Bryan R Nick, Niessen Wiro J, Windham Beverly G, DeStefano Anita L, Habes Mohamad, Heckbert Susan R, Palmer Nicholette D, Lewis Cora E, Eiriksdottir Gudny, Maillard Pauline, Mathias Rasika A, Homuth Georg, Valdés-Hernández Maria Del C, Divers Jasmin, Beiser Alexa S, Langner Sönke, Rice Kenneth M, Bastin Mark E, Yang Qiong, Maldjian Joseph A, Starr John M, Sidney Stephen, Risacher Shannon L, Uitterlinden André G, Gudnason Vilmundur G, Nauck Matthias, Rotter Jerome I, Schreiner Pamela J, Boerwinkle Eric, van Duijn Cornelia M, Mazoyer Bernard, von Sarnowski Bettina, Gottesman Rebecca F, Levy Daniel, Sigurdsson Sigurdur, Vernooij Meike W, Turner Stephen T, Schmidt Reinhold, Wardlaw Joanna M, Psaty Bruce M, Mosley Thomas H, DeCarli Charles S, Saykin Andrew J, Bowden Donald W, Becker Diane M, Deary Ian J, Schmidt Helena, Kardia Sharon L R, Ikram M Arfan, Debette Stéphanie, Grabe Hans J, Longstreth W T, Seshadri Sudha, Launer Lenore J, Fornage Myriam
Abstract excerpt
Background and Purpose- White matter hyperintensities (WMH) on brain magnetic resonance imaging are typical signs of cerebral small vessel disease and may indicate various preclinical, age-related neurological disorders, such as stroke. Though WMH are highly heritable, known common variants explain a small proportion of the WMH variance. The contribution of low-frequency/rare coding variants to WMH burden has not...
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