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Article

Association of Apolipoprotein E ɛ4 Allele with Enlarged Perivascular Spaces.

Annals of neurology - 1 Jul 2022

Pinheiro Adlin, Demissie Serkalem, Scruton Ashlea, Charidimou Andreas, Parva Pedram, DeCarli Charles, Seshadri Sudha, Romero José R

Abstract excerpt

OBJECTIVE: Enlarged perivascular spaces have emerged as markers of cerebral small vessel disease and are linked to perivascular drainage dysfunction. The apolipoprotein E-ɛ4 (APOE-ɛ4) allele is the strongest genetic risk factor for cerebral amyloid angiopathy and Alzheimer's neuropathology, but the underlying mechanisms remain unclear. We studied the relationship between APOE-ɛ4 and the topography and burden of...

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Identifiers

PMID: 35373386
DOI: 10.1002/ana.26364
PMCID: PMC9233108

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