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Article

Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo.

Development (Cambridge, England) - 1 Feb 2013

Guenatri Mounia, Duffié Rachel, Iranzo Julian, Fauque Patricia, Bourc'his Déborah

Abstract excerpt

A stimulatory DNA methyltransferase co-factor, Dnmt3L, has evolved in mammals to assist the process of de novo methylation, as genetically demonstrated in the germline. The function of Dnmt3L in the early embryo remains unresolved. By combining developmental and genetic approaches, we find that mouse embryos begin development with a maternal store of Dnmt3L, which is rapidly degraded and does not participate in...

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PMID: 23293288
DOI: 10.1242/dev.089268

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