Article
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration.
Cell reports - 23 Jun 2020
Socodato Renato, Portugal Camila C, Canedo Teresa, Rodrigues Artur, Almeida Tiago O, Henriques Joana F, Vaz Sandra H, Magalhães João, Silva Cátia M, Baptista Filipa I, Alves Renata L, Coelho-Santos Vanessa, Silva Ana Paula, Paes-de-Carvalho Roberto, Magalhães Ana, Brakebusch Cord, Sebastião Ana M, Summavielle Teresa, Ambrósio António F, Relvas João B
Abstract excerpt
Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in adult microglia is sufficient to trigger spontaneous microglia activation, producing a neurological phenotype (including synapse and neuron loss, impairment of long-term potentiation [LTP], formation of β-amyloid plaques, and memory...
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