Rescue of easily shocked mutant seizure sensitivity in Drosophila adults.

doi:10.1002/cne.23364

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Article

Rescue of easily shocked mutant seizure sensitivity in Drosophila adults.

The Journal of comparative neurology - 15 Oct 2013

Kroll Jason R, Tanouye Mark A

Abstract excerpt

Genetic factors that influence seizure susceptibility can act transiently during the development of neural circuits or might be necessary for the proper functioning of existing circuits. We provide evidence that the Drosophila seizure-sensitive mutant easily shocked (eas) represents a neurological disorder in which abnormal functioning of existing neural circuits leads to seizure sensitivity. The eas(+) gene...

Topics

Acoustic Stimulation
Animals
Crosses, Genetic
Drosophila melanogaster
Electrophysiological Phenomena
Heat-Shock Response
Mutation
Phospholipids
Phosphotransferases (Alcohol Group Acceptor)
Seizures
Synaptic Transmission

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Identifiers

PMID: 23682034
DOI: 10.1002/cne.23364
PMCID: PMC4023696

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