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Article

The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol.

Pharmacogenetics and genomics - 1 Sept 2010

Downing Chris, Marks Michael J, Larson Colin, Johnson Thomas E

Abstract excerpt

OBJECTIVE: Inbred long-sleep and short-sleep mice (ILS and ISS) were selectively bred for differential sensitivity to the sedative effects of ethanol. Lines of mice derived from these progenitors have been used to identify several quantitative trait loci (QTLs) mediating loss of the righting reflex due to ethanol (LORE). This study investigated the metabotropic glutamate receptor subtype 5 (mGluR5) as a candidate...

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Identifiers

PMID: 20657349
DOI: 10.1097/FPC.0b013e32833d8c20
PMCID: PMC2933419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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