Article
Roles of Prokineticin 2 in Subarachnoid Hemorrhage-Induced Early Brain Injury via Regulation of Phenotype Polarization in Astrocytes.
Molecular neurobiology - 1 Sept 2020
Ma Mian, Li Haiying, Wu Jiang, Zhang Yunhai, Shen Haitao, Li Xiang, Wang Zhong, Chen Gang
Abstract excerpt
Previous studies have postulated that neuroinflammation can induce two different types of reactive astrocytes, A1 and A2. A1 astrocytes may be harmful, whereas A2 astrocytes may be protective. Specifically, prokineticin 2 (PK2) has been shown to regulate neuron-astrocyte signaling mechanism by promoting an alternative A2-protective phenotype in astrocytes. This study aimed to examine the role of PK2 in early...
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