Article

Kv1.3 blockade alleviates white matter injury through reshaping M1/M2 phenotypes after intracerebral hemorrhage

2022-11-28

Abstract excerpt

<h4>Background: </h4> White matter injury (WMI) in basal ganglia usually induces long-term disability after intracerebral hemorrhage (ICH). Kv1.3 is highly expressed in microglia, and exaggerates neuroinflammation in neurodegenerative diseases. The present study investigated the role of inflammatory response resulting from Kv1.3 activation in WMI, as well as the effect of Kv1.3 blockade on microglia polarization a...

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Literature Corpus work: 8867cc89-4f82-5fa8-8e10-f39ecf2cc39c
DOI: 10.21203/rs.3.rs-2306209/v1

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