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Article

Longitudinal neuroimaging biomarkers differ across Alzheimer's disease phenotypes.

Brain : a journal of neurology - 1 Jul 2020

Sintini Irene, Graff-Radford Jonathan, Senjem Matthew L, Schwarz Christopher G, Machulda Mary M, Martin Peter R, Jones David T, Boeve Bradley F, Knopman David S, Kantarci Kejal, Petersen Ronald C, Jack Clifford R, Lowe Val J, Josephs Keith A, Whitwell Jennifer L

Abstract excerpt

Alzheimer's disease can present clinically with either the typical amnestic phenotype or with atypical phenotypes, such as logopenic progressive aphasia and posterior cortical atrophy. We have recently described longitudinal patterns of flortaucipir PET uptake and grey matter atrophy in the atypical phenotypes, demonstrating a longitudinal regional disconnect between flortaucipir accumulation and brain atrophy....

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Identifiers

PMID: 32572464
DOI: 10.1093/brain/awaa155
PMCID: PMC7363492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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