Article
Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer's disease: a neuropsychological data-driven approach.
Alzheimer's research & therapy - 6 Feb 2025
Putcha Deepti, Katsumi Yuta, Touroutoglou Alexandra, Eloyan Ani, Taurone Alexander, Thangarajah Maryanne, Aisen Paul, Dage Jeffrey L, Foroud Tatiana, Jack Clifford R, Kramer Joel H, Nudelman Kelly N H, Raman Rema, Vemuri Prashanthi, Atri Alireza, Day Gregory S, Duara Ranjan, Graff-Radford Neill R, Grant Ian M, Honig Lawrence S, Johnson Erik C B, Jones David T, Masdeu Joseph C, Mendez Mario F, Musiek Erik, Onyike Chiadi U, Riddle Meghan, Rogalski Emily, Salloway Stephen, Sha Sharon, Turner R Scott, Wingo Thomas S, Wolk David A, Womack Kyle, Carrillo Maria C, Rabinovici Gil D, Dickerson Bradford C, Apostolova Liana G, Hammers Dustin B
Abstract excerpt
BACKGROUND: The clinical presentations of early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease are distinct, with EOAD having a more aggressive disease course with greater heterogeneity. Recent publications from the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) described EOAD as predominantly amnestic, though this phenotypic description was based solely on clinical judgment. To...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.