Clinical and biomarker changes in dominantly inherited Alzheimer's disease.

doi:10.1056/NEJMoa1202753

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Article

Clinical and biomarker changes in dominantly inherited Alzheimer's disease.

The New England journal of medicine - 30 Aug 2012

Bateman Randall J, Xiong Chengjie, Benzinger Tammie L S, Fagan Anne M, Goate Alison, Fox Nick C, Marcus Daniel S, Cairns Nigel J, Xie Xianyun, Blazey Tyler M, Holtzman David M, Santacruz Anna, Buckles Virginia, Oliver Angela, Moulder Krista, Aisen Paul S, Ghetti Bernardino, Klunk William E, McDade Eric, Martins Ralph N, Masters Colin L, Mayeux Richard, Ringman John M, Rossor Martin N, Schofield Peter R, Sperling Reisa A, Salloway Stephen, Morris John C

Abstract excerpt

BACKGROUND: The order and magnitude of pathologic processes in Alzheimer's disease are not well understood, partly because the disease develops over many years. Autosomal dominant Alzheimer's disease has a predictable age at onset and provides an opportunity to determine the sequence and magnitude of pathologic changes that culminate in symptomatic disease. METHODS: In this prospective, longitudinal study, we...

Topics

Age of Onset
Alzheimer Disease
Amyloid beta-Peptides
Biomarkers
Brain
Cerebrospinal Fluid
Cross-Sectional Studies
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Dominant

Glucose

Humans

Longitudinal Studies

Magnetic Resonance Imaging

Male

Middle Aged

Mutation

Neuropsychological Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 22784036
DOI: 10.1056/NEJMoa1202753
PMCID: PMC3474597

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