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Article

Multidimensional cognitive deficits in the typical and atypical variants of Alzheimer's disease.

Alzheimer's research & therapy - 16 Oct 2025

Henderson Shalom K, Murley Alexander G, Cope Thomas E, Bowns Lucy, Malpetti Maura, Patterson Karalyn E, Rowe James B, Ralph Matthew A Lambon

Abstract excerpt

BACKGROUND: In this two-part investigation, we examined whether Alzheimer's disease (AD) phenotypes are distinct clinical entities or represent positions within a graded multidimensional space. METHODS: First, using a large retrospective dataset of past research participants (n = 413) from memory clinics, we examined the comparative distributions of cognitive performance in people diagnosed with typical amnestic...

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Identifiers

PMID: 41102738
DOI: 10.1186/s13195-025-01873-w
PMCID: PMC12532852

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