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Article

Sequential pathogenesis of metastatic VHL mutant clear cell renal cell carcinoma: putting it together with a translational perspective.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Sept 2016

Shenoy N, Pagliaro L

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) accounts for ∼80% of all RCC, and biallelic Von Hippel-Lindau (VHL) gene defects occur in ∼75% of sporadic ccRCC. The etiopathogenesis of VHL mutant metastatic RCC, based on our understanding to date of molecular mechanisms involved, is a sequence of events which can be grouped under the following: (i) loss of VHL activity (germline/somatic mutation + inactivation of the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Gene Expression Regulation, Neoplastic

Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Share to Von Hippel-Lindau Tumor Suppressor Protein

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Identifiers

PMID: 27329246
DOI: 10.1093/annonc/mdw241

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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