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Article

The genomic landscape of metastatic clear cell renal cell carcinoma after systemic therapy.

Molecular oncology - 1 Jun 2022

van der Mijn Johannes C, Eng Kenneth W, Chandra Pooja, Fernandez Evan, Ramazanoglu Sinan, Sigaras Alexandros, Oromendia Clara, Gudas Lorraine J, Tagawa Scott T, Nanus David M, Faltas Bishoy F, Beltran Himisha, Sternberg Cora N, Elemento Olivier, Sboner Andrea, Mosquera Juan Miguel, Molina Ana M

Abstract excerpt

Primary clear cell renal cell carcinoma (ccRCC) has been previously characterized, but the genomic landscape of metastatic ccRCC is largely unexplored. Here, we performed whole exome sequencing (WES) in 68 samples from 44 patients with ccRCC, including 52 samples from a metastatic site. SETD2, PBRM1, APC and VHL were the most frequently mutated genes in the metastatic ccRCC cohort. RBM10 and FBXW7 were also among...

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Identifiers

PMID: 35231161
DOI: 10.1002/1878-0261.13204
PMCID: PMC9208073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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