Article
Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein.
The Journal of biological chemistry - 14 Sept 2012
Dong Yuanshu, Zhang Lujuan, Zhang Sheng, Bai Yunpeng, Chen Hanying, Sun Xiaoxin, Yong Weidong, Li Wei, Colvin Stephanie C, Rhodes Simon J, Shou Weinian, Zhang Zhong-Yin
Abstract excerpt
The PRL (phosphatase of regenerating liver) phosphatases are implicated in the control of cell proliferation and invasion. Aberrant PRL expression is associated with progression and metastasis of multiple cancers. However, the specific in vivo function of the PRLs remains elusive. Here we show that deletion of PRL2, the most ubiquitously expressed PRL family member, leads to impaired placental development and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.