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Article

The emerging roles and therapeutic potential of cyclin M/CorC family of Mg2+ transporters.

Journal of pharmacological sciences - 1 Jan 2022

Funato Yosuke, Miki Hiroaki

Abstract excerpt

Cyclin M (CNNM) and its prokaryotic ortholog CorC belong to a family of proteins that function as Mg2+-extruding transporters by stimulating Na+/Mg2+ exchange, and thereby control intracellular Mg2+ levels. The Mg2+-extruding function of CNNM is inhibited by the direct binding of an oncogenic protein, phosphatase of regenerating liver (PRL), and this inhibition is responsible for the PRL-driven malignant...

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Identifiers

PMID: 34924118
DOI: 10.1016/j.jphs.2021.09.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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