Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer.

doi:10.1158/1078-0432.CCR-20-0638

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2020

Vidula Neelima, Dubash Taronish, Lawrence Michael S, Simoneau Antoine, Niemierko Andrzej, Blouch Erica, Nagy Becky, Roh Whijae, Chirn Brian, Reeves Brittany A, Malvarosa Giuliana, Lennerz Jochen, Isakoff Steven J, Juric Dejan, Micalizzi Douglas, Wander Seth, Spring Laura, Moy Beverly, Shannon Kristen, Younger Jerry, Lanman Richard, Toner Mehmet, Iafrate A John, Getz Gad, Zou Lee, Ellisen Leif W, Maheswaran Shyamala, Haber Daniel A, Bardia Aditya

Abstract excerpt

PURPOSE: Plasma genotyping may identify mutations in potentially "actionable" cancer genes, such as BRCA1/2, but their clinical significance is not well-defined. We evaluated the characteristics of somatically acquired BRCA1/2 mutations in patients with metastatic breast cancer (MBC). EXPERIMENTAL DESIGN: Patients with MBC undergoing routine cell-free DNA (cfDNA) next-generation sequencing (73-gene panel) before...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to Circulating Tumor DNA

Share to Exome Sequencing

Share to Neoplastic Cells, Circulating

Share to Phthalazines

Share to Piperazines

Share to Poly(ADP-ribose) Polymerase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 32571788
DOI: 10.1158/1078-0432.CCR-20-0638
PMCID: PMC7501190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer.PMID 32571788Read ↗

Comparative clinical utility of tumor genomic testing and cell-free DNA in metastatic breast cancer.Semantic proximity Read ↗

Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts.Semantic proximity Read ↗

Routine Plasma-Based Genotyping to Comprehensively Detect Germline, Somatic, and Reversion BRCA Mutations among Patients with Advanced Solid Tumors.Semantic proximity Read ↗

Detection of genomic alterations in breast cancer with circulating tumour DNA sequencing.Semantic proximity Read ↗

Circulating Tumor DNA Profiling From Breast Cancer Screening Through to Metastatic Disease.Semantic proximity Read ↗

Circulating tumour DNA in metastatic breast cancer to guide clinical trial enrolment and precision oncology: A cohort study.Semantic proximity Read ↗

The dynamic range of circulating tumor DNA in metastatic breast cancer.Semantic proximity Read ↗

Tumor Tissue- versus Plasma-based Genotyping for Selection of Matched Therapy and Impact on Clinical Outcomes in Patients with Metastatic Breast Cancer.Semantic proximity Read ↗

Detection of microsatellite instability high (MSI-H) status by targeted plasma-based genotyping in metastatic breast cancerSemantic proximity Read ↗

Genetic Alterations Detected by Circulating Tumor DNA in HER2-Low Metastatic Breast Cancer.Semantic proximity Read ↗

Next Generation Sequencing of Circulating Cell-Free DNA for Evaluating Mutations and Gene Amplification in Metastatic Breast Cancer.Semantic proximity Read ↗

Genomic analysis of plasma circulating tumor DNA in patients with heavily pretreated HER2 + metastatic breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.