Article
Next Generation Sequencing of Circulating Cell-Free DNA for Evaluating Mutations and Gene Amplification in Metastatic Breast Cancer.
Clinical chemistry - 1 Feb 2017
Page Karen, Guttery David S, Fernandez-Garcia Daniel, Hills Allison, Hastings Robert K, Luo Jinli, Goddard Kate, Shahin Vedia, Woodley-Barker Laura, Rosales Brenda M, Coombes R Charles, Stebbing Justin, Shaw Jacqueline A
Abstract excerpt
BACKGROUND: Breast cancer tissues are heterogeneous and show diverse somatic mutations and somatic copy number alterations (CNAs). We used a novel targeted next generation sequencing (NGS) panel to examine cell-free DNA (cfDNA) to detect somatic mutations and gene amplification in women with metastatic breast cancer (MBC). METHODS: cfDNA from pretreated patients (n = 42) and 9 healthy controls were compared with...
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