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Genomic analysis of plasma circulating tumor DNA in patients with heavily pretreated HER2 + metastatic breast cancer.

Scientific reports - 19 Jun 2023

Lee Kyoungmin, Lee Jongwon, Choi Jungmin, Sim Sung Hoon, Kim Jeong Eun, Kim Min Hwan, Park Yeon Hee, Kim Jee Hyun, Koh Su-Jin, Park Kyong Hwa, Kang Myoung Joo, Ahn Mi Sun, Lee Kyoung Eun, Kim Hee-Jun, Ahn Hee Kyung, Kim Han Jo, Park Keon Uk, Park In Hae

Abstract excerpt

We explored accumulated genomic alterations in patients with heavily treated HER2 + metastatic breast cancer enrolled in the KCSG BR18-14/KM10B trial. Targeted sequencing was performed with circulating tumor DNAs (ctDNAs) collected before the treatment of 92 patients. ctDNAs collected at the time of disease progression from seven patients who had a durable response for > 12 months were also analyzed. Sixty-five...

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Biomarkers, Tumor
Breast Neoplasms
Cancer Genomics and Diagnostics
Circulating Tumor DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Class I Phosphatidylinositol 3-Kinases

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Identifiers

PMID: 37336919
DOI: 10.1038/s41598-023-35925-8
PMCID: PMC10279711

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